The vascular system is one of the first to develop during embryo development and is essential for the maintenance and function of all organs and tissues in our body. A complex network of arteries, veins, and capillaries is formed early on and further organized to supply tissues and organs with oxygen, nutrients, and other essential molecules.
The inner lining of all blood vessels is composed of so-called endothelial cells, a single-layered cobblestone-like sheet of cells that play an important function as precise sensors of molecules and shear stress in blood. In response they regulate vessel tone, coagulation, cell differentiation, organ development and regeneration, among other things.
As such, endothelial cells are part of an important pathway for therapeutic intervention in multiple diseases including diabetes, atherosclerosis and cancer.
Experimental models of blood vessels can therefore contribute significantly to better understand the various human diseases and drug development. Stem cells (for our purposes, short for “human induced pluripotent stem cells”) are a prime tool to create better experimental in vitro models of the vasculature and can be used in specialized devices to mimic the human physiological environment.
Dr. Marchetti will illustrate experimental models of the vascular system including the usage of primary endothelial cells and the novel blood vessel organoid technology, among other things, in the context of vascular disease.
Valentina Marchetti obtained her PhD in experimental physiopathology at the University of Rome (Tor Vergata) Italy. She subsequently moved to the USA where she spent 5 years as post-doctoral fellow at The Scripps Research Institute, studying the usage of stem cells and myeloid cells for treating diabetic retinopathies and neurodegenerative diseases of the eye.
In the last 8 years she has been working in an industry environment, at STEMCELL Technologies, Vancouver, Canada, where she is responsible for establishing, validating and developing products for supporting endothelial stem cell biology research. In the last year she has also been extensively collaborating with several laboratories and has been an active part of an international group investigating the new SARS-COV-2 role in vascular diseases.
She has recently been appointed Adjunct Professor, in the Department of Molecular Biology and Biochemistry at Simon Fraser University. She is the author of numerous publications on key regulators of insulin resistance, vascular inflammation and microvascular complications related to cardiovascular diseases, as well as the roles of stem cells in diabetic retinopathies and cell therapy applications.
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ITALIAN RESEARCH IN THE WORLD DAY
This event is organized in collaboration with the Consulate General of Italy in Vancouver to celebrate the Italian Research in the World Day, instituted starting in 2018 as part of the Piano Straordinario "Vivere all'Italiana" - Giornata della ricerca Italiana nel mondo.
The establishment of an Italian Research Day in the World was announced by the Italian Minister of Education, University and Research, Valeria Fedeli, during a visit to the CERN Laboratories in Geneva. The celebration day was chosen by government decree to be every year on April 15 on the anniversary of the birth of Leonardo da Vinci.
The main objective of the Italian Research Day in the World is to value the quality and competencies of Italian researchers abroad, but also to promote concrete actions and investments to allow Italian researchers to continue pursuing their careers in their homeland. Italy wishes to enable Italian talents to return from abroad as well as to become an attractive environment for foreign researchers.
April 13, 2022 at 7:00PM
Online Event - Register to Receive the Stream Link