ARPICO and The Consulate General of Italy PRESENT:
A Gut Feeling: The Impact of Industrialization on our Inner Ecosystem
This event is a collaboration with the Consulate General of Italy in Vancouver in celebration of Italian Research Day in the World instituted in 2018 to value the quality and competencies of Italian researchers abroad and promote concrete actions and investments to allow Italian researchers to continue pursuing their careers in their homeland as well as make Italy an attractive environment for foreign researchers.
A Gut Feeling: The Impact of Industrialization on our Inner Ecosystem
a talk by Dr. Carolina Tropini
The trillion microbes that live in our bodies profoundly influence our health and are sensitive to environmental interactions. Despite our extensive knowledge, we've overlooked their responses to physical changes, particularly in our guts, which consist of diverse environments shaping microbial populations. Factors ranging from minor illnesses to grave diseases like cancer can alter gut conditions, impacting microbial communities positively or negatively.
Carolina Tropini's work uses a mix of clinical studies and advanced laboratory technologies to closely watch how the gut environment changes during medications use or illnesses. This work helps us to understand how small changes at the level of individual microbes can lead to big shifts in the entire community in the context of diseases such as inflammatory bowel disease.
An exciting aspect of this research is the opportunity to leverage the findings to develop novel methods for early disease detection. But why does industrialization matter in all of this? Industrialization has dramatically changed our diets, our exposure to chemicals, and our lifestyles, all of which can have a big impact on our gut microbes. The shift towards processed foods, increased use of medications, and changes in living conditions can disrupt the delicate balance of our gut microbiota. This disruption can make us more susceptible to diseases and can even affect how well we respond to treatments. By exploring how the physical conditions in the gut influence microbial communities, Carolina Tropini's research not only fills a gap in our understanding, but also opens up new possibilities for treating diseases by targeting the gut microbiome. This approach could lead to more personalized and effective treatments, improving our overall health and well-being.
Dr. Carolina Tropini is an Assistant Professor at the University of British Columbia, holding a Canada Tier 2 Research Chair in Quantitative Microbiota Biology for Health Applications. She is a Paul Allen Distinguished Investigator and was the first Canadian to receive the Johnson & Johnson Women in STEM2D Scholar award in Engineering in 2020. Dr. Tropini is also the inaugural Alan Bernstein CIFAR Fellow in the Human & the Microbiome Program and a Michael Smith Foundation for Health Research Scholar. Her lab investigates how disrupted physical environments due to altered nutrition or intestinal diseases affect microbiota and hosts at multiple scales. They use cross-disciplinary approaches, combining microbiology, bioengineering, and biophysics to study bacterial and microbial community functions, aiming to translate findings into improving human health. Dr. Tropini completed her Ph.D. in Biophysics at Stanford University, focusing on bacterial mechanics and morphogenesis, and conducted postdoctoral research at Stanford on physical perturbations' impact on host-associated microbial communities in the gut.
REGISTRATION
Please register online via EventBrite at https://agutfeeling.eventbrite.ca/
April 10, 2024 at 7:00 PM
Museum of Vancouver - History Room - 1100 Chestnut Street, Vancouver, BC, V6J 3J9
Event Follow-up
On April 10th, 2024, ARPICO was delighted to welcome approximately 75 attendees to its 2024 season inaugural public event held in conjunction with the Celebration of the Italian Research Day in the World in collaboration with the Consulate General of Italy in Vancouver, continuing a tradition started in 2018. The event was held in the History Room of the Museum of Vancouver. This year it was also attended by the Scientific Attachée from the Embassy of Italy in Ottawa, Professor Costanza Conti on her first visit to western Canada since the start of her mandate in January 2023.
We were honoured to host our speaker Professor Carolina Tropini from the university of British Columbia and originally from Turin, Italy. The focus of her research is the human gut microbiota which are composed by over trillion microbes that live in our body; and it turns out that the microbiota are greatly influenced by the environment outside our body.
A topic so closely related to our inner physical health and nutrition was bound to be of wide interest; the room was indeed completely full, hardly leaving space for the food service tables.
Professor Tropini took us on a tour of was constitutes the human microbe population, what the microbes feed on (including food type recommendations!) and how to keep them healthy. She hardly used specialized jargon, but instead drew analogies with familiar macroscopic situations. For example, a healthy microbiota was represented by a lush forest inclusive of diverse flora and fauna; as a healthy forest promotes wellbeing for its fauna and flora, a healthy microbiota plays an essential role in maintaining health including positively affecting the immune system. She explained that the effect of antibiotics, an effect of industrialization, especially if over-prescribed, makes the forest look as devasted by a major fire; careful re-population of its essential species is therefore needed in order to revive it. (Note that she did fully acknowledge the life-saving impact of antibiotics!). And since each of us has their own unique microbiota, the impact of the industrialized world may differ from person to person; learning the links between the impact of the industrialized world on the microbiota itself and an individual’s diseases may thus be key to personalized and more effective prevention and treatments. She actively pursues research in this area, including studying the effect of fecal matter transplantation, which has shown promise in re-establishing healthy microbiota in selected cases.
Her clear and informative talk was followed by a rich Q&A session before we regrouped in a reconfigured venue which allowed attendees to enjoy the excellent Mediterranean food and wine sponsored in part by the Italian Consulate and provided by our friend caterers Bottles & Bottega.
An overall successful event thanks to the outstanding team work of ARPICO’s board and an indefatigable team of additional volunteers. A special mention goes for Gabriella Sacchetti. She not only did superb organizational work, but also undertook a long drive with Antonio from their new home in Stony Plain, Alberta to be here for the event. Her presence was much appreciated!
Coming next from ARPICO: a talk by Philippe Tortell on understanding climate change from research in the Arctic, on June 19th 2024. We are looking forward to another exciting evening!